Collagen Films Obtained from Collagen Solutions Characterized by Rheology

The Formation of Fibrils from Collagen Solutions

The kinetics of collagen reprecipitation from solutions of salt-extracted calf dermis in the presence of small amounts of mucopolysaccharide and nucleic acids (0.005 per cent in the final reaction mixture) has been reported by Wood (1960). The present paper is a parallel study using the same materials, and describes the electron microscopic (EM) morphology of the collagen precipitates replicate...

Cell Invasion in Collagen Scaffold Architectures Characterized by Percolation Theory

The relationship between biological scaffold interconnectivity and cell migration is an important but poorly understood factor in tissue regeneration. Here a scale-independent technique for characterization of collagen scaffold interconnectivity is presented, using a combination of X-ray microcomputed tomography and percolation theory. Confocal microscopy of connective tissue cells reveals this...

The formation of fibrils from collagen solutions. 2. A mechanism of collagen-fibril formation.

Size-dependent rheology of type-I collagen networks.

We investigate the system size-dependent rheological response of branched type I collagen gels. When subjected to a shear strain, the highly interconnected mesh dynamically reorients, resulting in overall stiffening of the network. When a continuous shear strain is applied to a collagen network, we observe that the local apparent modulus, in the strain-stiffening regime, is strongly dependent o...

Structure and rheology of gelatin and collagen gels.

This paper undertakes a parallel analysis of the gelation mechanisms, structure and rheological properties of gelatin and collagen gels. Although the molecular compositions of collagen and gelatin are almost identical, gelation proceeds from distinct mechanisms and leads to different types of molecular assemblies. First are presented the properties of the solutions, based on their structural an...